Mitochondrial Genes: Their Origin and the Effects of MutationsPhotosynthesis: Harvesting Light Energy

New medical box on the use of protein kinase inhibitors in cancertherapy II BIOENERGETICS AND METABOLISM The Evolution of Oxygenic Photosynthesis Box 19–1 Hot, Stinking Plants and Alternative Respiratory Pathways Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry. Purpose: The goal is to provide students with a thorough biochemistry text. Given the overall importance of modern biochemistry (broadly writ), this is a worthwhile objective. In general, the goals are met. Tools for understanding are provided including ‘Key Conventions’ and ‘Special Themes’ (Metabolic Integration, Obesity, and Diabetes, Evolution) as well as ‘Medical Insights and Applications-Icons’ used throughout the book denote material of special medical interest and updated to reflect the most current content.

The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry’s foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research. New information on HMG-CoA reductase and new medical box on statins 22 Biosynthesis of Amino Acids, Nucleotides, and Related Molecules

Case Studies’ introduce students to a biochemical mystery and allows them to determine what investigations will solve it. Accompanying assessments ensure that students have fully completed and understood the case study, showing that they have applied their knowledge of the concepts.Lehninger Principles of Biochemistry 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. Obesity, the Metabolic Syndrome, and Type 2 Diabetes Box 23–1 Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment 15 Principles of Metabolic Regulation Chemical Logic discusses the common biochemical reaction types that underlie all metabolic reactions, helping students to connect organic chemistry with biochemistry.

Interactive Molecular Figures allow students to view and interact with textbook illustrations of protein structures online in interactive 3-D models for a better understanding of their three-dimensional structures. The Glyoxylate Cycle Box 16–1 Moonlighting Enzymes: Proteins with More Than One Job Box 16–2 Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! The definitive Lehninger Principles of Biochemistry, Eighth Edition, continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new coauthor Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. New box on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity 25 DNA MetabolismNew medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax) The summary of principals and the highlighting of these principals throughout the text. This is really helpful! The Boxes with additional information, particularly clinical relevance of the material. Most of my students are pre-med and it helps them engage in the material better if there is clinical relevance. The problems at the end of the chapter. These are really beneficial for the students who want to make sure they understand the material." --Robin Haynes, Harvard University Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway